Those using a sled microtome will hold the material in a sliding shuttle. They can then move the material across the blade’s surface, which will slice away a small part of it. Preparation of some samples will require infusion of an epoxy or paraffin in order to turn the sample into a solid. A rotary microtome allows for sectioning to take place in a liquid nitrogen chamber. A laser microtome is another option. This allows the user to create very precise cuts. It can work well for soft tissue samples, as well as for harder materials, such as bone. One of the benefits of using the laser microtome is that it eliminates needing to touch the sample physically, which reduces the chance of any contamination.